Dear Renaldo,

I have never worked on that line.

But, i got some references, which may be helpful to u.

1) Journal of Chemical and Pharmaceutical Research, 2014, 6(5):1076-1088

2) Molecules 2012, 17, 6179-6195; doi:10.3390/molecules17066179

3) MUHAMAD_FARIDZ_BIN_OSMAN_09_24.pdf

4) Analele Universităţii din Bucuresti – Chimie (serie nouă), vol 20 no. 1, pag. 15 – 24

5) Chetana B Patil et al /J. Pharm. Sci. & Res. Vol.1(3), 2009, 11-22.

6) Choudhary et al., Int J Pharm Pharm Sci, Vol 3, Issue 3, 2011, 125128

7) ecsoc-12_1247_original.pdf

Dear Renaldo,

I never worked with Chalcone.

But, i am sending you some references....which may be helpful to you.

1) MUHAMAD_FARIDZ_BIN_OSMAN_09_24-1.pdf

2)Molecules 2012, 17, 6179-6195; doi:10.3390/molecules17066179

3) Journal of Chemical and Pharmaceutical Research, 2014, 6(5):1076-1088

4) Chetana B Patil et al /J. Pharm. Sci. & Res. Vol.1(3), 2009, 11-22.

5) ecsoc-12_1247_original.pdf

6) Analele Universităţii din Bucuresti – Chimie (serie nouă), vol 20 no. 1, pag. 15 – 24

7) International Journal of Pharmacy and Pharmaceutical Sciences

 Vol 3, Issue 3, 2011, ISSN- 0975-1491

8) Int J Pharm Bio Sci 2012 July; 3(3): (P)389 - 395

I don't know, whether these will help u or not. best of luck for your research.

Dissolve 2-Hydroxyacetophenone (1 mmol) in 95% ethanol (# 2 mL) on ice bath (0-5 C), then add KOH (1.5 mmmol, dissolved in the minimum amount of water 50-100 ul) and continue stirring until the color of the mixture changes (30-60 min). Then add the solid DMAB (1.2 mmole) in a portion wise manner (within one hour). Continue stirring on ice/room temperature while monitoring the reaction progress by TLC; usually the Rf of the new product should be between the Rf of the starting materials. After the reaction completes (TLC proof), dissolve the reaction mixture (should be like a paste) in ice cold water with vigorous stirring, then collect the product by vacuum filtration or extraction by DCM. 

Dear Rexy Renaldo

You dissolve 2-Hydroxyacetophenone (1 mmol) in a least amt. ethanol (7 mL) and then then add KOH and/or NaOH (1.5 mmmol, dissolved in the minimum amount of water (1-2 mL) ) and stirrfor about 1-2 h. Then add excess  solid DMAB (1.2 mmole) in about 1 h. Complete stirring for further 2hs., then add water and neutralize it with little acetic acid. Filter, or extract with ethyl acetate or methylene chloride.

Good luck

Prof. Dr. Talaat El-Emary

Try supported Ce(III) for activation of both presented C=O groups.

For inspiration see

https://www.researchgate.net/publication/276059289_Kabachnik-Fields_and_Prins-Ritter_Synthesis_Application_of_Ce%28III%29_Supported_on_a_Weakly_Acidic_Cation-exchanger_Resin_in_Comparative_Study?ev=prf_pub

https://www.researchgate.net/publication/267390365_Comparative_Studies_of_Catalytic_Application_of_Cerium%28III%29_Chloride_and_Resin_Supported_Cerium%28III%29_in_Domino_Syntheses_of_15-Benzodiazepine_and_13-Diazine_Skeletons?ev=prf_pub

https://www.researchgate.net/publication/265959505_Synergism_of_Metal_and_Organocatalysis_in_Condensation_Reactions_of_Aromatic_Aldehydes_with_Anilines_Affording_Imines_Effect_of_Catalysts_on_the_Base_of_a_Supported_Cerium%28III%29_and_Proline?ev=prf_pub

Article Kabachnik-Fields and Prins-Ritter Synthesis: Application of ...

Article Comparative Studies of Catalytic Application of Cerium(III) ...

Article Synergism of Metal and Organocatalysis in Condensation React...

I agree with Dr Sikat Sen

Most of the synthetic methods leading to the chalcone involve reacting 2′-hydroxyacetophenone and 4-(dimethylamino)benzaldehyde in presence of NaOH/KOH, followed by careful neutralization of the reaction mixture (this converts the phenoxide moiety in the product to a free phenol) with 5% HCl till a pH between 4-6 is reached.

Just perform the reaction in cold conditions especially acidification

Dear Rexy

Please, find in attach a paper on formation of chalcones usong KOH/EtOH.

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF

NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIROHETEROCYCLIC

DERIVATIVES. By: Shawkat A. Abdelmohsen, Talaat I. El-Emary

Journal: Journal of Advances in Chemistry

Vol. 10, No. 7