Is osmolality and pH important in subcutaneous injection solution?

I making a subcutaneous formulation of conc. 20mg/ml in aqueous solution with cosolvent NMP. The pH of formulation is 6.55 and osmolality is 1352 mOsm that is the formulation is hypertonic. Is it...

09 June 2019 9,509 1 View

Is there any good coupling interfaces available for ANSYS (FEM) and EDEM (DEM)?

Actually I am thinking to apply it for a bulk of non-spherical particles in a storage faciltity

21 May 2018 8,719 4 View

From where can I download Global/Regional Nitrogen Deposition data for India ?

Historical and present both.

14 December 2017 3,155 2 View

GROMACS and flat-bottom position restraints

Hi, I want to know whether the flat-bottom position restraints can be applied only for the pull code in umbrella sampling or it can be use for NPT or MD simulation of GROMACS (not umbrella...

23 May 2017 8,190 1 View

Oscillator function model for eosin yellow?

19 October 2016 8,647 9 View

Can we know the doped materials surroundings voids by refinemnet the XRD using MAUD?

From the refinement by MAUd we can generate CIF file which help to get the crystallographic structure of the material. But in case of doped material how the refinement should be changed to...

22 July 2016 4,191 3 View

How can I convert distribution of interface state density in terms of voltage to energy distribution?

I use hf C-V and conductance method to determine the interface state density of MOS structures in terms of voltage. I am not able to show the distribution in terms of energy. How do i convert the...

02 April 2015 4,463 3 View

How long does it take to degrade target transcripts by siRNA?

Typically, the effect of siRNAs are assayed after 48hrs. During this period, the siRNA is expected to "keep degrading" the existing as well as newly synthesized transcripts. Now, if there is a...

16 December 2014 5,021 4 View

Do eRNAs remain attached with the template DNA or are detached and float around?

The last couple years have seen several reports of enhancer RNAs (eRNAs and similar transcripts) that aid enhancer- and activator-dependent transcription. Arguably, a chunk of 5' end of the eRNA...

26 August 2014 2,518 4 View

Is there a protein that binds DNA stoichiometrically and sequence-nonspecifically?

For some experiments, I need a control for DNA binding of proteins; and I need a protein that binds DNA sequence-nonspecifically, and, equally importantly, stoichiometrically. Does anyone know of...

21 January 2014 2,665 5 View

What techniques can I use to determine the miscibility of polymer blends?

The term miscibility refers to the single-phase state in thermodynamics. I do not mean the compatibility of different components. To determine the miscibility I know several techniques such as...

03 March 2021 4,107 4 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

What analysis to choose with a large neste dataset and clearly skewed or kurtotic distributions?

Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...

02 March 2021 6,865 1 View

How to calculate BREQ 3 questionnaire?

how to calculate BEHAVIOURAL REGULATION IN EXERCISE QUESTIONNAIRE BREQ 3 ,which contain 24 questions and each question has 5 answers (0- Strongly disagree , 1-disagree, 2- Neither agree nor...

02 March 2021 811 3 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

Please suggest a good text book for "Research Methodology in Life Sciences". Which book would be good for PhD Scholars?

Please provide Book Title and author name

02 March 2021 9,059 3 View

Could any one guide me, to write research proposal for grant? ?

We have one plant, the local people using this for controlling blood sugar, the toxicity and antidiabetic activity of the plant is not reported yet, please guide from whag should be the process ?...

02 March 2021 2,300 1 View

Shall I skip the measurement model in SmartPLS?

Hello everyone, I had run a mediation model in SmartPLS using questionnaires that were already validated among my statistical population. A professor who edited my paper -though she is not...

01 March 2021 3,052 3 View

What is involved in morphological changes of SEM images of a substance?

In the sem analysis of CaCO3 nanaoparticles, the morphology images showed spherical shaped particles but the proposed morphology for these type of nanoparticles is trigonal. I prepared the...

01 March 2021 1,960 4 View

I have designed reflectarray element and feeding it though Horn Antenna on HFSS. After full wave simulation, I am not getting desired results?

I have designed reflectarray element to generate OAM beams at 5.8GHz and feeding it though Horn Antenna on HFSS. After full wave simulation, i am not getting desired results i.e Radiation pattern...

01 March 2021 9,701 5 View