microRNA can be used in two forms of mimic and inhibitors and based on different type of disease they can be representative of the pathologic condition, for example in cancer miR-let7 is downregulated and for treatment, it's better to use its mimic and also miR 125 is upregulated which is better to be inhibited.I hope this won't make you confused. 

Thanks for your interest Masoume.

Yes, I agree, but what I would need is to have some information about the expression of this microRNA and with what kind of pathology it has been related. In the literature so far there is no data.

these are the paper that I found for this microRNA:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835794/

https://link.springer.com/article/10.1134/S1068162015040147

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609948/

I hope these can help you.

Best Regards,

Masoumeh

The miR-1b precursor is interesting as it appears to be completely antisense to the miR-1a precursor. In this regard it is an antisense miRNA (which is relatively rare). Comparison of sequencing reads for miR-1a and miR-1b reveals a massive difference, as the former is very abundant, whereas the latter is much less abundant. For both precursors the 3prime arm is favoured, so miR-1b-5p is a rare form of a rare miRNA. Indeed, in miRBase, only 11 reads map to this miRNA out of a combined 108 experiments in mouse. For the human, the miR-1b has now been removed form the database. I would be quite cautious about pursuing this miRNA - but perhaps you have some fantastic data on this interesting locus!

Thank you very much for your help to both Masoume and Thomas.

Effectively, the limited existing bibliography is related to other organisms and my interes is in humans, but it is clear that it must be a very minoritary microRNA.