I am doing a MCAO stroke with craniotomy, in rats addicted to sucrose. While the survival rate of normal rats is more then 80% with free access at glucose 1% and water the survival rate now is lower than that.
It will be helpful to know if somebody else has experience with this model and is this low survival rate is because of sucrose intake or something else.
If animal is dying within 2 to 4 hr It may depends upon anesthesia you used for experiment and their dose. It is always better to use gaseous anesthesia for quick recovery. High amount of sucrose may cause dizziness, unconsciousness but exactly death will occur, I am not confirm.
Thank you for your answer.
The problem is that animals died after 12-14 hours. Also this animals were old (18-24 mounts).
Thank you again for your response!
Bogdan
Last time i forget to mentioned that age of mice should be 8-10 week; for rat it should be 16-20 week other wise their tolerance towards stroke is less. So, this may be one of the reason for dying of animal. Old rat having less survival rates.
Thank you for your answer! Do you have a reference for this information?
Bogdan Catalin
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