Hello!

A group (Carroll et al, 2015) has used CRISPR system to edit MYH6 gene in a mouse model. It can probably point you to a direction in using this methodology at your research.

Best regards.

Reference:

Kelli J. Carroll, Catherine A. Makarewich, John McAnally, Douglas M. Anderson, Lorena Zentilin, Ning Liu, Mauro Giacca, Rhonda Bassel-Duby, and Eric N. Olson

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

PNAS 2016 113: 338-343. (doi: 10.1073/pnas.1523918113)