Personal experience with desensitization: This is best for patients with hight Ig E. The treatment is for 2 years 6 months. The patients begin have not crisis at 3 months of treatment. And increase in weight. If you will make one study with this parameters, Please put my name in this. Thanks.

Thanx for you response

Immunotherapy has been in practice for many years in asthma and rhinitis.  In atopic subjects, with a selected small number of allergens which are clinically relevant, there seems to be improvement.  Yet, these patients are on conventional treatment too and I am not aware of any long term studies on ONLY immunotherapy in asthma.  Desensitisation worked well in allergic conjunctivitis in South India some years ago.

Thanks for the valuable information

Allergen immunotherapy is an evidence based treatment of asthma induced by inhalant allergens, as showed by a number of meta-analyses.

The allergic specific immunotherapy is most effective treatment for IgE mediated diseases.It change the naturale course of disease.I work 16 years with SCIT andSLITH and I have very good resiltes.You can finfd it in my papers,

Many thanks,I will look into your papers.

I worked as professor in the department of pulmonary medicine in Kasturba Medical college, Manipal in India for about 9 years. Our department had trained technicians for  allergy testing and I used to order allergy testing (Skin prick technique) whenever allergen cause was suspected by history for those presenting with  rhinitis/rhinosinusitis or asthma and the tests were done routinely in the ward. Allergen specific Immunotherapy against a maximum of  six allergens were offered to selected patients of allergic rhinitis/asthma. The symptomatic relief or reduced dosage requirement of drugs was evident more often in those with rhinitis or rhinitis with asthma after atleast one year of treatment. The symptomatic relief with immunotherapy  for asthma alone was less. There were no major adverse effects with immunotherapy. At that time, we did not have access to sublingual immunotherapy.  

Many thanks for sharing this valuable information and experience ,I really hope its published

Good Days Tarig Eltoum and K. Gowrinath.

Estimate K Gowrinath, good work, sublingual inmunotherapy was realized for and inmunologist in Guayaquil- Ecuador (Dr. Manuel Maldonado) with good results in little childrens.

Thanks a lot for sharing the information with me.

Hi Tarig,

Interesting question. My answer is yes I have a lot of experience and it is very positive. But as you know expert's opinion is the lowest grade of evidence. So I recommend to search medical database for systematic reviews and meta analysis. There is a recent one by Virchow et al. in WAO Journal. Anyway in oder to have nice results you have to meet the following criteria: 1. Use high quality allergen therapeutical extracts - preferably for SLIT; 2. Recommend AIT to patients with clinically relevant sensitization as confirmed by medical history, SPT and sIgE; 3. AIT is most successful in patients with rhinitis and asthma sensitized to HDM and pollen allergens. Do not use it in pet sensitization, recommend avoiding the allergen instead. AIT with insect allergens is a tricky matter, what is more only formulas for SCIT are available. I hope that is of some help.

Thanks a lot

Interesting topic.

You have a great experience so could I ask you if you are aware of any long-term side effects of desensitization? Like a higher prevalence of autoimmune diseases or any other diseases?

I haven't found any papers about that but it would be great to hear your personal opinion.

Theoretically, desensitization is an effective modality but those who practices do not opine high about it.