How to draw or color shade the aromatic rings?

I have seen recent literature which publishes molecules with colored graphics. I understand, software such as Chemdraw, ChemDoodle helps in drawing colored bonds. However, these software doesn't...

10 November 2016 385 0 View

How can we apply for own funding to support our postdoctoral application in UK universities?

I am looking for the information on funding agencies to support my postdoctoral studies in UK universities. My prospective supervisor had advised me to bring own funding to support my application....

04 May 2016 4,284 0 View

How do you detect singlet oxygen and calculate its quantum yield by phosphorescence?

I wanted to measure the quantum yield of singlet oxygen by phosphorescence. In this regard my questions are: 1. How much concentration is required? 2. Do I need to measure both in aerated and...

10 November 2014 6,645 7 View

How to purify a sulfonated porphyrins or the other organic compounds?

I have prepared sulfonated porphyrins and purified by soxhlet extraction. But MALDI-TOF analysis showed other impurities. I would appreciate if you could suggest me some suitable method to purify...

08 September 2014 2,351 5 View

Is chloroform suitable for cell culture experiments?

Please suggest me whether minimal amount of chloroform (0.1%) is suitable to use in cell culture experiments. As my organic compound shows degradation behavior in DMSO solvents, I prefer using an...

07 August 2014 5,350 15 View

How can I measure Laser power using a power meter?

I wanted to measure Laser power for using it in a biological application. I can understand that as the distance of the laser is adjusted, the beam/spot size is also varied and subsequently power...

07 August 2014 8,548 5 View

Does anyone have knowledge Sulfonation of Thianaphthene (Benzo[b]thiophene)?

06 July 2014 3,937 1 View

Can anyone help me with a DLS measurement?

Could anyone suggest what the refractive index and viscosity value should be for DMEM cell culture media and PBS buffer at 25 C. This is required for measuring zeta potential and particle size...

05 June 2014 7,065 6 View

Can I perform ester hydrolysis reaction in "sealed tubes"?

I wanted to perform a reaction in a sealed tube. My reaction is ester hydrolysis. Since I use less amount of THF as solvent, its hard for me to maintain the reaction condition for long time under...

03 April 2014 7,252 6 View

How can one optimize the geometry of inorganic metal complexes?

I am working with synthesis of metal complexes. I am interested to use computational chemistry such as geometry optimization methods to support my metal complexes. But I am not aware of those...

11 December 2013 5,703 10 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Why does two different bioinformatics tools for the same proteins show different subcellular localizations?

During a computational analysis, I found that for a protein of a plant, two different subcellular localizations are seen using CELLO and WoLF PSORT. For example, in CELLO, it identified the...

01 March 2021 6,729 2 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

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19 February 2021 8,647 3 View

How to improve dissolution of neosome?

I have made neosome from herbal drug. Neosomes are stable. But I face problems in dissolution. I used minimum ratio of 1:1:0.25 ( Drug:span 60: Cholesterol and GMs. Now how can I active better...

17 February 2021 3,584 1 View

Does the property of GFP affect a fusion protein's localization?

Hello, I am planning to insert GOI between CaMV 35 promoter and mGFP in pCambia1302 to produce a fusion protein and see subcellular localization of the protein. But the vector says it's membrane...

15 February 2021 4,353 3 View

How to determine the drug loading and the drug release capacity of a polymer micelle using UV spectroscopy?

Currently, I am working on PLA-PEG copolymer micelle for the drug delivery system. I have seen several papers where some researcher talks to centrifuge the drug-loaded micelle to separate the...

13 February 2021 5,822 7 View