If a bacteria bearing the resistance gene for an antibiotic is grown in presence of the antibiotic, how slow will it be compared to its native form (where it does not have the resistance gene containing plasmid) grown in normal growth conditions? Ideally as it has the resistance gene already, the growth rate of the bacteria should not be slowed down by the antibiotic, although initially the protein needs to be synthesised, but after a few generations, the plasmid will produce more and previous molecules will also be there, so, after a lag the normal growth rate should be restored. Or some minute differences in the growth rate will always be there?
Antibiotic resistance in bacteria can be achieved when mutations in a ribosome or protein change the site where an antibiotic binds. For example, tetracycline, streptomycin, kanamycin, and spectinomycin.
Ribosomal mutations, while providing antibiotic resistance for the organism, slow the process of protein synthesis, slow growth rates, and reduce the ability of the affected bacterium to compete in an environment devoid of a specific antibiotic.
Furthermore, a mutation that confers resistance to one antibiotic may make the bacterium more susceptible to other antibiotics. Please read the following paper:
http://www.icr.org/article/evolution-antibiotic-resistance/
Please kindly find link below for some answers:
http://www.engr.colostate.edu/~ashokp/Teaching_Biology/Antibiotic_Resistance_files/Antibiotic%20Resistance%20Write-Up.pdf
https://academic.oup.com/jac/article/49/1/25/658364/Factors-impacting-on-the-problem-of-antibiotic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390829/
Hi Tias,
I think the following links will help you:
http://aac.asm.org/content/54/5/2085.full.pdf+html
https://www.nature.com/nrmicro/journal/v8/n4/pdf/nrmicro2319.pdf
Typically, yes it will slow growth of the resistant bacteria down. There is a metabolic burden associated with producing the plasmid that harbors the antibiotic resistance cassette.
Antibiotic resistance in bacteria can be achieved when mutations in a ribosome or protein change the site where an antibiotic binds. For example, tetracycline, streptomycin, kanamycin, and spectinomycin.
Ribosomal mutations, while providing antibiotic resistance for the organism, slow the process of protein synthesis, slow growth rates, and reduce the ability of the affected bacterium to compete in an environment devoid of a specific antibiotic.
Furthermore, a mutation that confers resistance to one antibiotic may make the bacterium more susceptible to other antibiotics. Please read the following paper:
http://www.icr.org/article/evolution-antibiotic-resistance/
Hi Tias
antibiotic affect the growth rate of resistant bacteria because bacteria has sensing system that sense the outer environment. This sensing system affect the regulation of other gene. There are many ways for regulation. Like that mpt gene is down regulated in bacteria that shows resistance against antimicrobial peptides and growth also slow down.
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