Through comparative proteome and immunohistochemistry, we found some molecules showed higher expression in IBS than the normal controls. Those molecules are very new for intestine or IBS, at first, we wish to understand their roles in IBS or functional gastrointestinal disorders based on the clinical data, then, to explore their basic mechanisms and the therapeutic potential with experiments.
If anyone have interest in this research please join us, especially, welcome the clinical researchers who can provide the samples and data of IBS patients.
Thank you for your concern. Can you develop a clinical test of our IBS biomarkers in Jordan? If yes, we will discuss about the details.
I have studied patients with thoracic disc hernia and in my serie 66% were diagnosed as IBS. May be that ethiology of illness in some patients with symptomatology of IBS is due to a thoracic disc hernia. It could be helpfull for you
I am interested in participating in the study providing samples and data of our IBS patients
I'm also interested in this study providing the samples and data of IBS patients
Thanks to Drs. Czako and Sitkin. I am glad you are interested in this initiative. I hope many people to take part in this to make a multicenter research. Dr. Czako, I will send you a email to talk about the project. Dr. Sitkin, please send me your message to my email [email protected].
We are also interested in this study providing the samples and data of our IBS patients. We continued to study environmental and dietetic factors in IBS. So we can be a part of a multicenter study. [email protected]
Dear Dr Guo, I am a gastroenterologist interested in clinical gastroenterology. As my interest does not end as soon as I pulled back the scope, I am confronted with IBS very often. Yet, first of all, in my opinion, IBS is a symptom complex, not a disease by itself. I rather would consider it a pool of different diseases (or disorders) resulting in more or less the same symptoms. Therefore, when treating my patients my goal is to identify the patient's specific disorder as good as possible and then treat it as targeted as possible. This approach does not promise 'heaven on earth', but at least sometimes it leads to long lasting symptoms relieve (or cure).
As I think that such a project bears the potential to identify specific disorders, if the involved centres are thinking the same, can work out an algorithm of mandatory investigations to exclude specific diseases, and, if agreed on, can work out another algorithm to subdivide potential functional abnormalities, then I am very interested to provide my thoughts, include my patients with data, tissue and blood samples as needed.
For more details, contact me by [email protected]
Thanks for this initiative, Bruno Strebel
Thanks to all you guys. We are writing a draft for the collaboration of multicenter research. I will send those who are possible to join us in the following days.
@Drs. Bruno Strebel and Francisco Javier Pérez Lara : As IBS is very complicated and lack of accurate diagnostic methods. I am very interested to explore the causes of IBS. Accumulating evidence of IBS patients and animal models show that there is something critical for IBS. Once we discovered the core mechanism, the diagnosis and treatment will be clear.
@Dr. Bruno Strebel: As you mentioned, till now there is no consensus what IBS is. IBS just sounds to be a nomenclature of a group of symptoms. Your consideration should be take into account. Your job makes a good attempting and bring us a new idea to IBS. It is necessary to analyze the details to know what is common or critical elements for the development of IBS and what is the different or special ones. If your treatment is useful, did you make a clinical valuation? Is there any clue to lead us to understand the underlying mechanism? I always believe it will push IBS research forward faster when combined with the more clinical evidence and more effective intervention.
Dear Dr Guo, I am interested in participating in the study that you propose to conduct. It would be great if could let me know the outline of the study, and the protocol you are proposing for it including diagnostics. I am available for contact at [email protected]
The focus of my research, metadata in nature as I am an engineer and not a medical doctors, has shown as strong correlation between an increase in glutamate receptors in the the vagus nerve and its branches, and I suggest you focus your research there. This is the reason som eIBS sufferers find relief from amitriptyline, after a few weeks teh incraesed serotonin downregulates
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