BioMed Research International (JCR/2014 – IF = 1.57)

Special Issue on “RECENT PROGRESS IN CYCLODEXTRINS USES”

CALL FOR PAPERS

In the last 30 years there was a progressive increase in the number of publications and patents related to the production of Cyclodextrins (CDs). Cyclodextrins are a family of cyclic oligosaccharides composed of a-(1,4) linked glucopyranose subunits. These compounds having supramolecular structures carry out chemical reactions that involve intramolecular interactions where covalent bonds are not formed between interacting molecules, ions or radicals. CDs can be considered as empty capsules of a certain molecular size that can include a great variety of molecules in this cavity. In this case, a complex called ‘‘inclusion complex’’ is formed. Inclusion complexes are entities comprising two or more molecules. One of the molecule, the ‘‘host’’, includes, totally or partly, the ‘‘guest’’ molecules by physical forces. CDs possess a special ability to complex with drugs enabling them to increase solubility, reduce bitterness, enhance stability, and decrease tissue irritation upon dosing. One of the most common applications of CDs cited in the pharmaceutical literature is the enhancement of bioavailability. Most of the studies attribute the influence on bioavailability to the solubilizing capabilities of CDs, although some also discuss other CDs effects, such as effects on physical or chemical stability. The interaction of CDs with biological membranes and possible associated changes in permeability has also been investigated. In the last years, several reviews also described the use of CDs in food and flavor. CDs have been recommended for applications in encapsulation of flavors, protection against oxidative degradation, heat-induced changes and light-induced decomposition, and food preservation.

So, this special issue of the BioMed Research International will aim to disseminate scientific articles focused on complexation techniques, drug release from CDs complexes, in vitro and in vivo assays, toxicity studies, metabolism and pharmacokinetics and solubility–permeability interplay applied pharmaceuticals, flavors and food.

- Analytical techniques for characterization of cyclodextrin complexes

- Cyclodextrin-based supramolecular systems for drug delivery

- Pharmacological evaluation of inclusion complexes

- Enzymatic production and food applications

- Ability of cyclodextrins to enhance bioavailability

- Toxicity and pharmacokinetics evaluation of cyclodextrins

- Cyclodextrins as encapsulation agents for plant bioactive compounds

- Biotechnological applications of cyclodextrins

- Improvement of pharmacological property by complexation in cyclodextrin: In vitro and in vivo studies

Authors can submit their manuscripts via the Manuscript Tracking System at

http://mts.hindawi.com/submit/ journals/bmri/biotechnology/ rpcu/

Time schedule

Manuscript Due                    -  2015-10-30

First Round of Reviews        -  2016-01-22

Publication Date                    -  2016-03-18

Guest Editors

Lucindo J. Quintans-Júnior, Federal University of Sergipe, Brazil; [email protected]  

Adriano A. S. Araújo, Federal University of Sergipe, Brazil; [email protected]  

Daniel I. Hadaruga, Polytechnic University of Timişoara, Romania; [email protected]  

Ashish Baldi, I.S.F. College of Pharmacy, Ghal Kalan, Ferozpur G.T. Road Moga, Punjab. [email protected]