The concept of antipsychotic equivalence has been used for decades to compare the dosages and efficacy of antipsychotics, even though it is highly debatable, and with the widespread of atypical antipsychotics also highly criticized, because the antipsychotic effect is not only an isolated result of the blockade of dopamine D2 receptors.
What about you? Do you use the so-called chlorpromazine equivalent (CPZE) in your research? What are the other ways to compare the doses and effectiveness of antipsychotics?
Dear Michal,
such as you rightly said, the antipsychotic effect isn't just an isolated result of the blockade of dopamine D2 receptors nor even the dopamine receptors only, so we surely need new methods to compare the effectiveness of different antipsychotics. I think this article can be helpful to you.
Best regards
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696254/
Thank you, yes, I've already read it. For my research, I need some comparison of antipsychotic doses. Do you have any other tip?
Thank you! For a longer time I think that when comparing antipsychotics, haloperidol is a better reference substance than chlorpromazine.
May be the following references would be useful:
However, I have not been able to find the dose equivalents for long acting antisychotics.
The concept of the neuroleptic threshold was introduced nearly immediately after the advent of neuroleptics, I think by Kulenkampf. And reached its end when Clozapin was commercialised, that can even be used to improve Parkinson's disease. I think that splitting according to clinical response, globally and domain-specific, might be more appropriate.
I agree with you Dirk Ulbricht. Surely splitting according to clinical response, globally and domain-specific, might be more appropriate, but sometimes we might need eg in an antipsychotic comparative study to have an equivalent dose of reference.
I think it's one of the reason why we find in literature tables like the one I published.
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