Currently, the in-slico approach is considered fundamental, and in general precedes in-vitro and in-vivo studies since its primary role is dedicated to the prediction of the possible biological properties of one or more compounds due to its high algorithmic precision and its database which is frequently updated.
Hello Mohamed Sabri Bensaad
I would say not reliable but helpful.
In-silico software have been employed to find or to improve a novel bioactive compound, which may exhibit a strong affinity to a particular target. Actually, a world view underlying the theory and methodology of in-silico toxico-pharmacology is still in progress and shows a broad spectrum of opportunities to help in the discovery of new targets and finally to result in substances with high affinity and possible biological/pharmacological activity on those tested targets.
In-silico approaches should be accompanied by further in vitro and in vivo experiments to verify the biological activities. Unfortunately, there are lots of identified compounds (by in-silico screening methods), which have not been evaluated in vitro or in vivo in order to prove the real positive responses.
For more information you can refer to the link below.
https://scialert.net/fulltext/?doi=ijp.2013.176.181
Best.
Dear Malcolm Nobre,
Thank you so much for all these informations and clarifications. it's very kind of you.
Best wishes
In silico approaches in drug discovery is reliable if they are performed properly. Of course, experimental validation should be done, however, several advanced in silico techniques can now achieve a high success rate, particularly in the field of enzyme inhibition. For example, predicting the binding free energy of a specific drug molecule to a certain enzyme can be achieved with very good accuracy (R2 = 0.9).
In my opinion, in the near future in silico methods will be an integral part in chemical biology and will be of trustful accuracy and precision.
Dear Ahmed,
Thank you so much for your answer and for all these clarifications.
Best wishes
Thank you so much dear Dr Jose Risomar Sousa for sharing with us your opinion.
Dear respected Dr,
RESEARCH COOPERATION
I read your papers
I am Asso. Prof. Dr Rokayya in Taif University Saudi Arabia, in food science
I read several papers of you and get into your research gate and google schooler
I have similar publication as your field
and thanks god published 30 papers in 2021
Total Publication: 74 ISI: 41 Scopus: 9 Academic: 5 Conference: 3 Others: 6
my account is
https://scholar.google.com/citations?view_op=list_works&hl=ar&user=o8ML5SUAAAAJ&gmla=AJsN-F48pP7O73jfdvmZ1uL6_-d2Mg_ilX2dP_TwmOKo3FUhUMHrCGMrtH7LX_NXo2_nhywmwYGKcXfwDpbwagNOmP5pzex_x9kOj_lQliq_z0ictTjG95-JxUIWMABVlsQ0V8RE6ApyhuxWfyF5jy-Y7OJ2g9imTw
you can get in and check my publication
We can cooperate with each other to publish more papers in our field food science and nutrition and chemistry
i can write your name in my next ISI paper and you can write my name too if possible and support you with publication fee
welcome to hear from you
00966545706156 MY PHONE
Prof. Dr. Rokayya Eldib
Associated professor at Department of Food Science and Nutrition - College of science - Taif University - Kingdom of Saudi Arabia
Dear Dr Rokayya Sami,
Thank you for your offer, it's very kind of you.
Best wishes,
Sabri
- Badges
- Science topic
- Similar topics
- Mathematical Sciences
- Statistics
- Probability
- Probability Theory
- Reliability