Tumor suppressor genes (such as Rb, APC, PTEN and the ever famous p53) are often downregulated in cancer cells, if not completely lost or dysfunctional.
I'd like to know if there are any tumor suppressor genes that are upregulated in metastatic cancer cell lines/models? If so, could you link to articles/publications/studies of such genes? Are these genes bi-modal? Or have people figured out the molecular mechanism behind these genes?
I'd appreciate any and all help provided.
Thank you.
DRG1? http://cancerres.aacrjournals.org/content/60/3/749.short
I know I saw many papers, but sorry, I'm not a cancer signaling guy. There are many studies only looking for gene expression in metastasis, mainly in colon cancer
Of course, p53 comes to mind: http://jcb.rupress.org/content/192/2/209
To Lark and Oliver: Thank you for your replies. But to my understanding, both genes that you've linked are tumor suppressor genes that are downregulated in cancers that have undergone the metastatic process, or are genes that have gained a mutation.
I'm looking for particular tumor suppressor genes that are upregulated in highly metastatic cancers without any mutation on the gene & its product.
Thank you! I hope this clarifies what I'm looking for.
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