We are looking for mouse females that do have normal ovaries but do not have germ cells (no oocytes). I know that some of the different Sl or W alleles that can give that phenotype but I would like to know if there are others mutant lines.
Thanks!
Stéphane
Toni Yeasky
Yes, I work with WvWv homozygous mice which have a cKit mutation. They are sterile due to no germ cells and do have signs of early menapause, such as osteoperosis, high cholesterol and slight cardiomyopathy. They get tubular adenomas in ovary but are over all healthy and live a normal life span.
0 votes
0 thanks
Liangwen Zhong
NOBOX，GDF9 etc is female specific gene, knockout mice show female infertility
0 votes
0 thanks
Elanor N Wainwright
You could use busulfan-treatment to deplete germ cells or stop-floxed DTA line crossed with specific germ cell cre
0 votes
0 thanks
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Disease Models
- Animal Models
- Rodent Models
- Mouse Models
Similar questions and discussions