Phenolic compounds could be potentially effective in the treatment of various skin disorders, including signs of aging, diseases and injury. Numerous studies have shown the potent biological activity of polyphenols, especially in skin cell cultures, a reconstituted skin model and rodents (mice, rats). Plant phenolics possess a significant potential to inhibit or even reverse the signs of aging, such as wrinkles or hyperpigmentation marks; hence they are promising molecules for development of new cosmetic formulations. On the other hand, particular phenolic compounds may act in a specific and effective way in order to inhibit or slow down the development of various skin-related diseases. The plant phenolics may be efficient in the treatment of both serious life-threatening dermal diseases (cancer) and minor skin problems (acne). Despite the beneficial influence of polyphenols on the skin aging effects and dermal diseases, they were also reported to be effective in healing of wounds (including chronic wounds) and burns. As regards skin disorders, therapeutic properties were shown by either a single compound or a combination of phenolics present in the plant extracts. The natural character and high effectiveness of phenolic compounds are promising features for developing novel topical formulations and dressings that might replace hitherto known remedies with limited application.

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