As we know mutations are in the DNA level whether they are permanent or somatic , why we can not call RNA editing(splicing and shuffling) and Protein Modification as mutations.
Hi Nagarjun, Carlo correctly indicated that for mutation we intend a permanent change in the genome.. In a broad meaning the change can interest from one or few base pairs ( point mutations), to cytogenetic variations, but let's talk about point mutations. These can also be named DNA variants, which is a more "neutral" term.
Point mutations or DNA variants may affect proteins (changing their aminoacidic sequence, introducing premature stop codons or eliminating one) and the changed protein can aldo be named mutant.
Splicing generates mRNA variants named splicing isoforms. However, some point mutations may affect donor, acceptor or branching site
Carlo and Paola made it clear. Just one more thing need to be a bit careful when you mention this. Mutations in DNA might not be active if it's never been transcribed, and other mutations in non-coding region could lead to RNA changes, including editing, or splicing, like paola mentioned mutation in splice sites, or enhancer/silencer regions.
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Biology
- Biomolecules
- Nucleic Acids
- DNA