The skeletal muscle cells accumulate glycogen. Would the increase in glucose uptake trigger an over production of glycogen granules and this, in turn, push the mitochondria close to the nuclei?
Dear Mario,
would you mind to inform about the background of your request: is it biochemical or structural (microscopic - if yes, which kind of microscopic localization method? ) evidence you think mitochondria are pushed close to the nuclei of muscle cells? I admit that (using TEM) I have seen a lot of "diseased" human muscle fibres with plenty of "normal", 'abnormal, pleoconical to megaconial' mitochondria, eventually with paracrystalline inclusions most of the times in subsarcolemmal localization, sometimes also interspersed within sarcomeric filament bundles, and as well in iuxtanuclear position. Most of the times there was slight to also prominent deposition of glycogen (particles, or patchy distribution) (depending on the underlying disease), sometimes ending up with virtual glycogen lakes....where only few mitochondria were located inside those lakes [as if they were "destroyed" or "degenerated" (' choked, suffocated, extincted' ] but in the case of (fibrillar) "glycogen bodies" often some accumulation of mitochondria could be noted around those areas. Please define more in detail whether you study (animal) muscle metabolism 'experimentally" or (human) muscle altered due to neuro-muscular disease. Thank you in advance....
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