This is good question.

Resistane mre caused by many reasons. One of them is due to genetic determinants located in bacterial chromosome....Probiotics can produce antibiotics such as reuterin,or bacteriocins or diacetyl and such substances can cause curing of the antibiotic resistane gene and the antibiotic resistant organism could be changed in some cases to sensitive. It is good and recommended point for study in vitro and in vivo.

Many reasons also cause antibiotic resistane and probiotics can help in decrease the resistance 

Dear Aalla, there is a recent paper related to your question.

Best regards.

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

https://www.researchgate.net/publication/316463036_Next-generation_probiotics_the_spectrum_from_probiotics_to_live_biotherapeutics

Article Next-generation probiotics: The spectrum from probiotics to ...

Thanks all researchers for the valuable answers.

Dr. Aalaa,

Probiotics are live microorganisms, mainly belonging to the genera Lactobacillus and Bifidobacterium, although also strain of other species are commercialized, that have a beneficial effect on the host. From the perspective of antibiotic use, probiotics have been observed to reduce the risk of certain infectious disease such as certain types of diarrhea and respiratory tract infection. This may be accompanied with a reduced need of antibiotics for secondary infections. Antibiotics tend to be effective against most common diseases, but increasingly resistance is being observed among pathogens. Probiotics are specifically selected to not contribute to the spread of antibiotic resistance and not carry transferable antibiotic resistance. Concomitant use of probiotics with antibiotics has been observed to reduce the incidence, duration and/or severity of antibiotic-associated diarrhea. This contributes to better adherence to the antibiotic prescription and thereby reduces the evolution of resistance. To what extent probiotics directly reduce the spread of antibiotic resistance is still much under investigation; but maintaining a balanced microbiota during antibiotic use may certainly provide opportunities for reducing the spread of resistances. Key messages Probiotics may reduce the risk for certain infectious diseases and thereby reduce the need for antibiotics. Probiotics may reduce the risk for antibiotic-associated diarrhea Probiotics do not contribute to the spread of antibiotic resistance and may even reduce it

Thank you so much Dr. Aamal .

https://www.optibacprobiotics.co.uk/blog/2014/07/can-probiotics-prevent-antibiotic-resistance

Thank you Dr. Ali hadi Ghawi

Yes. Please see the following RG links.

Poster Combating antibiotic resistance by the use of probiotics

Article Probiotic approach to prevent antibiotic resistance

Article Combating antibiotic resistance through probiotics

Definitely, as probiotics are beneficial live organisms which have immunomodulatory properties and help in treating dysbiosis due to antibacterial resistance.

Please go through the link below:

Article Antibiotic resistance and probiotics: Roles, mechanisms and evidence