Dear Nasim Nosoudi

osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins.

Osteoblast are cuboidal mononuclear bone cells 15-30 µm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.

The single nucleus is eccentrically placed and the abundant rough endoplasmic reticulum is characteristic of a cell engaged in protein synthesis. There is also a high level of alkaline phosphatase. Vesicles containing amorphous calcium phosphate may also be present.

These bone cells are connected together and to the processes of subjacent osteocytes by gap junctions. Inactive bone surfaces are lined by a monolayer of flattened cells which are thought to be resting osteoblasts

Osteogenic cells, the bone stem cells, undergo mitosis. Some children remain osteogenic cells, some children become osteoblasts.

Osetoblasts can't do mitosis. They do build bone. The kind of paint themselves into a corner. Then they are called osteocytes, and have different behaviors than when they were osteoblasts. No mitosis necessary to change behavior.

Osteoclasts, the bone destroyers, do not undergo mitosis either. Nobody is really sure where the hell they came from. Some books say they come from monocytes. Some books say they are a merging of several blood-based (not bone-based) stem cells. If it is poorly understood, it won't be tested in the MCAT.

https://www.boundless.com/biology/textbooks/boundless-biology-textbook/the-musculoskeletal-system-38/bone-216/cell-types-in-bones-816-12058/

But invitro. Pls. look at page 100 in: Robert Marcus, David Feldman, Dorothy Nelson, Clifford J. Rosen. 2007. Osteoporosis Academic Press, Pp. 2016. ISBN0080553478, 9780080553474

http://boneandspine.com/bone-cells/

https://www.ncbi.nlm.nih.gov/pubmed/15781466

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066433/

https://en.wikipedia.org/wiki/Osteocyte

Hoping this will be helpful, if so use the green arrow

Regards

Prof. Houda Kawas

Dear Nasim Nosoudi

osteoblasts large, granular cells, can't undergo mitosis, found on surface of bone form bone, secrete the osteoid: collagen, proteoglycans, glycoproteins.

Osteoblast are cuboidal mononuclear bone cells 15-30 µm in length, which form a contiguous monolayer over the surface of bone. They are derived from marrow stromal cells by differentiation of pre-osteoblasts and not themselves undergo mitosis.

The single nucleus is eccentrically placed and the abundant rough endoplasmic reticulum is characteristic of a cell engaged in protein synthesis. There is also a high level of alkaline phosphatase. Vesicles containing amorphous calcium phosphate may also be present.

These bone cells are connected together and to the processes of subjacent osteocytes by gap junctions. Inactive bone surfaces are lined by a monolayer of flattened cells which are thought to be resting osteoblasts

Osteogenic cells, the bone stem cells, undergo mitosis. Some children remain osteogenic cells, some children become osteoblasts.

Osetoblasts can't do mitosis. They do build bone. The kind of paint themselves into a corner. Then they are called osteocytes, and have different behaviors than when they were osteoblasts. No mitosis necessary to change behavior.

Osteoclasts, the bone destroyers, do not undergo mitosis either. Nobody is really sure where the hell they came from. Some books say they come from monocytes. Some books say they are a merging of several blood-based (not bone-based) stem cells. If it is poorly understood, it won't be tested in the MCAT.

https://www.boundless.com/biology/textbooks/boundless-biology-textbook/the-musculoskeletal-system-38/bone-216/cell-types-in-bones-816-12058/

But invitro. Pls. look at page 100 in: Robert Marcus, David Feldman, Dorothy Nelson, Clifford J. Rosen. 2007. Osteoporosis Academic Press, Pp. 2016. ISBN0080553478, 9780080553474

http://boneandspine.com/bone-cells/

https://www.ncbi.nlm.nih.gov/pubmed/15781466

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066433/

https://en.wikipedia.org/wiki/Osteocyte

Hoping this will be helpful, if so use the green arrow

Regards

Prof. Houda Kawas