Do mice cough or can a irritant (capasaicin) cough response in mice be measured?

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Mark Birrell

No, mice and rats do not appear to have the cough reflex (Guinea pigs do)

their afferent sensory arm is intact though, so tussive agents like the TRPV1 agonist capsaicin can trigger nerve depolarisation

Stefano Gaburro

Dear Mark,

what do you then think of the publication attached previously?

Thanks.

Best Regards,

Peter West

Mark would know more about this than me but I think this boils down to how people define how a mouse/rat reacts to capsaicin inhalation. It isn't to say that they don't respond to capsaicin as Mark said but some would say that physiologically the response is not a cough just an expiration.