Different longevity manipulation may be needed at different life stages:
What I discovered in my master thesis in my analysis of microarray gene expression patterns of yeast 12 hours, 18 hours, 24 hours and 48 hours past exposure to caloric restriction when compared to normal yeast growth media is that the variation in gene expression pattern at these 4 different time points (8 conditions) is much higher when compared to changes in gene expression pattern caused by knockout mutations. Therefore, I’d like to think of each individual at different time points in its life more like as a different genotype or at least transcriptase type, who’d benefit from a different set of anti-aging interventions. Anti-aging interventions, which are beneficial for a 20 year old, might be detrimental of a 70 year old. Hence, I believe we also need to stratify the development of anti aging interventions by lifespan intervals, e.g. for 20-30 year old, 31-40 year old, etc.
Based on my experience from D. melanogaster I would say: Yes.
Article Life extension and the position of the hormetic zone depends...
hi
https://www.ncbi.nlm.nih.gov › NCBI › Literature ›
https://academic.oup.com/.../article/.../Dietary-Interventions-to-Extend-Life-Span-and
It´s an intriguing idea but it will be very difficult to transfer it to humans. I am not aware of an intervention study running over decades and it will be extremely difficult to find a sponsor with long term tenacity.
But I know from my own life experiences that relatively long phases of stable physiology are separated by relative brief phase of rapid changes between them. For example, when I turned 40, I rapidly gain weight over a six months period and then staid the same for a long time. Its even much more obvious in women, whose physiology remains stable until they lose their ability to have children, when it changes rapidly over a year or so before transitioning into another relatively long physiologically consistent post-menopausal phase. I believe that the developmental genes, which control our transitions from baby to toddler, from toddler to child, from child to teenager, from teenage to young adult, from young adult to middle-aged, from middle-aged to old and from old to death are functioning like a pre-programmed suicide lock forcing the transition from old into death by similar mechanisms by which the transitions between the other age-stages characterized by metabolic and physiologic unique differences. Even though humans lack the very drastic transitions between the developmental phases of worms, flies, frogs or butterflies their less obvious - but nevertheless - highly conserved and reproducible temporally brief - but nevertheless - rapid metabolic and physiological changes are separating that much longer lasting metabolically and physiologically much more stable intervals, which resemble the different developmental phases observed in worms, flies, frogs and butterflies, except for that the different developmental stages in vertebrates don't differ as much from one another. But nevertheless the mechanism for transitioning between different phases regardless how similar or different they may be from one another seems to be highly conserved. Since they are not the same even in humans something must cause the transition making each transition a check point of the life cycle, which appears to be regulated analogously to the cell cycle. The cell cycle can be halted b preventing the accumulation of proteins above a critical threshold, when - when exceeded - overcomes the checkpoints, which separates the cell cycle into its phases., Do the proposed life cycle checkpoints, which are separating life into distinct phases, also require the accumulation of regulatory proteins above a certain threshold before the transition into the next phase of life can occur? If so, could we extend lifespan by simply preventing the accumulation of transition-inducing regulatory proteins from exceeding the threshold below which no transition into an older-age phase can occur? Should we try to use the temporary barriers, which seem to temporarily halt the transitions between different life phases until certain conditions for progression are met, by - similar to cell cycle check points - form life cycle check points - to trap humans, worms, files or frogs in an early life phase by preventing the progression across the proposed life cycle checkpoints separating life phases from one another, to trap individuals permanently at the end of their early life phases indefinitely; thus, making them immortal because they can no longer transition into their next phase of life?
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