Do exist any approved to human (or, at least, near to be) anti-inflammatory drugs, alternatives to NSAIDs?

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Siva G Somasundaram

You may find few in the following article: Generally the natural products derived from Food are safe and long lasting.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011108/

I have worked on Apigenin flavonoid which is a good alternate found in dried parsley leaves.

Chandra Somasundaram

Yes for people, who can not use NSAIDs and have already GI issues.

Can dried parsley leaves relief the acute pain as ibuprofen does? it may be safer having no side effects and help for mild to moderate pain. For example, suddenly, I had a sharp neck pain for the first time, 200mg ibuprofen relieved it in less than 30 minutes. That is more important than worrying about the minute (insignificant) side effect of 200mg ibuprofen might cause.

Mohamad Ahmadian

Hello

You can use herbs such as ginger and curcumin

Open this link

https://translate.google.com/translate?hl=en&sl=fa&u=http://econews.com/fa/content/548264&prev=search

Dmytro Yashchenko

Thanks to all for answers! I've conducted some search and also found only herbal compounds. I always had some bias against herbal medicine, but as I can see a lot of scientific data has appeared in last 10 years. There are promising achievements appeared in pharmacology regarding to herbal compounds, such as improving bioavailability, improving in producing standartized extracts, etc. Herbal compounds potentially can reduce inflammation by suppressing NF-kB, inhibiting leukotriene biosynthesis, immunomodulating, basophil membranes stabilization, etc. Of course, unlikely they will be so effective as NSAIDs in the therapy of acute pain, but it may be a real alternative to NSAIDs for the therapy of chronic inflammation, especially for the people with gastrointestinal and cardiovascular diseases. As I think, the most promising are: Zingiberaceae, boswellia serrata, bidens tripartita. The data of basic science couldn't be ignored. However, the evidence is unclear and bias can not be excluded. Large and accurate trials should be conducted to give strict implication for practice.

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Update. Conducted search revealed another one plant with large pharmacological potential, that can help in acute pain too - Mytragina speciosa. It is not well known in our country (I first saw it recently on pubmed), but as I can see widely known in english-language world. Its compounds, especially mytraginin and 7-hydroxymitragynine demonstrated both anti-inflammatory and antinociceptive effects. However, there is controversy about its abusing potential and toxicity due to its opioid activity. Although its toxicity and abusing potential much more smaller than in most other opioid receptors agonists. There were 15 kratom-related deaths in the United States between 2014 and 2016. However, confirmation of the contributing toxic effects of mitragynine was lacking, also were found another substances during the autopsy: propylhexedrine; acetaminophen, morphine, and promethazine; temazepam, diphenhydramine, and dextromethorphan. Apparently, they were chronic various drug users. I've not found any cases when mytragina caused death independently. Just opinion - there are much more alcohol related deaths. However, further investigations needed to indicate mytragina clinical benefits and limitations. No adequate trials on humans were found.

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Trudy J. Rumann Heil Behrendsen

Dear Dmytro Yashchenko,

Great question! I just happen to know of an FDA approved drug when used off-label will act as an anti-inflammatory and docks in the opiod receptor for about 40 minutes when taken sublingual. I personally have used it for 9 years with excellent results. The website with the information is: www.mpkb.org It is an exciting retargeted use for olmesartan medoxomil (Benicar) My unpublished research can be found at: www.np-privatepracticeassoc.com

Trudy Heil MS, ARNP, LNC, Ret.

Henry R Wolfe

Low dose colchicine (0.6 mg) has an anti-inflammatory mechanism through the NLRP3 pathway (independent of steroids) and is indicated for the treatment of acute gout pain, chronic treatment and the inflammatory disease Familial Mediterranean Fever. A review article on its mechanism is on my ResearchGate homepage for download