Do any one know if the refractory AML cases gene EXPRESSION profiling is affected by subcutanous low dose AraC as a palliative treatment?

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Bruce Lyday

Ara C can influence apoptotic gene expression (Bax, Bcl-2, etc.), I would guess that refractory cases would have higher levels of anti-apoptotic genes, and would be more resistant to S-phase chemotherapeutic agents. See link

Good Luck

Bruce

http://www.nature.com/cdd/journal/v10/n9/full/4401259a.html

Fatma Abdel Wahab

Thanks Bruce