Some cases of refractory AML are given low doses of chemotherapy , would that affect their gene expression profiling ?
Ara C can influence apoptotic gene expression (Bax, Bcl-2, etc.), I would guess that refractory cases would have higher levels of anti-apoptotic genes, and would be more resistant to S-phase chemotherapeutic agents. See link
Good Luck
Bruce
http://www.nature.com/cdd/journal/v10/n9/full/4401259a.html
Thanks Bruce
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