DPLD with increased lung volumes could be: lymphangioleiomyomatosis or pulmonary Langerhans cell histocytosis. Also, idiopathic bronchiolitis obliterans, could be a differential. Of course, emphysema could be superimposed to any DPLD.
The presence of alterations related to diseases in which interstitial connotation exquisitely clinic are connected with a more or less severe restriction (decreased TLC, FRC), in some conditions it may be associated in the situation spirometric lung volumes in the standard or even increased. If this condition is not related to a condition of pulmonary emphysema in a smoker, that after the long history of exposure to cigarette smoke, or independently of it, develops pulmonary fibrosis syndrome (combined), and if that condition is not to be a SRIF (smoking-related interstitial fibrosis: Journal of Clinical Pathology April 2013 epub ahead of print - Katzenstein AL) then they can be taken into consideration due to other diseases such apparent clinical morphological divergence: sarcoidosis, HP, RB-ILD, pulmonary LCG, LAM among others, and ILD associated with asthma (chronic eosinophilic pneumonia, Churg-Strauss syndrome). Obstructive defect without significant airflow restriction may also reflect obliterative bronchiolitis (constrictive bronchiolitis)
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