Do the synthesis in water?

Solvent free mechanochemistry.

Solvent free microwave chemistry.

you can check the 12 principles of green chemistry:

https://www.acs.org/greenchemistry/principles/12-principles-of-green-chemistry.html

I hope this helps

Try to synthesize molecules without any additives like solvent catalyst,

if it fails then try water, Ethylene glycol, PEGs, ScO2, etc. try it at room temperature, if it didn't work try in visible light as an energy source, sonication or microwaves. If you get good yield at the end then you can say the protocol is green or sustainable .

Few points:

1. Solvent selection: Traditional organic synthesis often involves the use of large amounts of volatile and hazardous solvents. Green chemistry aims to minimize or eliminate the use of such solvents or replace them with greener alternatives. Water, for instance, is a widely used green solvent due to its low toxicity, abundance, and recyclability. Other green solvents include ethanol, supercritical carbon dioxide, and ionic liquids.

2. Catalysts: Catalysts play a crucial role in organic synthesis by accelerating reactions and improving reaction selectivity. Green chemistry emphasizes the use of catalysts that are efficient, selective, and environmentally benign. For example, transition metal catalysts, enzymes, and organocatalysts are often employed in green synthesis due to their high activity and low toxicity.

3. Renewable feedstocks: Green chemistry promotes the use of renewable feedstocks derived from biomass or other sustainable sources. These feedstocks can replace petroleum-based starting materials, reducing the environmental impact and dependence on fossil fuels. Biomass-derived sugars, vegetable oils, and lignocellulosic materials are examples of renewable feedstocks used in green synthesis.

4. Atom economy: Atom economy refers to the efficient utilization of atoms in a chemical reaction, minimizing waste generation. Green chemistry encourages the design of synthetic routes with high atom economy, where the majority of reactant atoms are incorporated into the desired product. This reduces the generation of byproducts and waste, making the synthesis more sustainable.

5. Energy efficiency: Green chemistry seeks to optimize energy usage in chemical synthesis. This can be achieved by employing mild reaction conditions, such as lower temperatures and pressures, to minimize energy consumption. Techniques like microwave heating and ultrasound-assisted synthesis are also used to enhance reaction rates and reduce energy requirements.

6. Recycling and waste reduction: Green chemistry aims to minimize waste generation and promote the recycling or reuse of materials. Strategies include designing reactions with minimal byproducts, implementing efficient separation techniques to recover and recycle catalysts or solvents, and exploring innovative methods for waste treatment or conversion into valuable products.

7. Process optimization: Green chemistry involves optimizing the overall synthetic process to improve efficiency and reduce environmental impact. This may include process intensification techniques like continuous flow chemistry, automated synthesis, and optimization algorithms to minimize resource consumption, reaction time, and waste generation.

Hope it helps:credit AI

Multiple ways

1. cost effective approaches

2. using greener solvents or without solvents

3. mechanochemical approaches

4. reducing reaction steps

5. microwave reactions etc

Kindly see my profile you wl find research articles of your interest and understanding.

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Mohammad Imam , Jaya Pandey , Malik Abdul Waseem Waseem , Jf Pons , Richard Symes , Guobing Xiang