Dear friend Preeti Sidraya Shinde

I hope this message finds you well! It sounds like you’re working on some truly fascinating nanoparticle synthesis, especially with your focus on mesoporous silica nanoparticles (MSNs) in the 500–1000 nm range and pore sizes above 10 nm. Achieving these specific dimensions can be challenging, but there are several strategies and resources that might help streamline your process.

One effective approach is the surfactant-templating method, which is widely used for materials like MCM-41, SBA-15, and dendritic silica. By adjusting the surfactant type and concentration, and incorporating swelling agents such as trimethylbenzene (TMB), you can often expand the pore size to meet your requirements. This technique is particularly well-documented in studies on SBA-15 synthesis.

I recommend reviewing research by Zhao, Stucky, and Huo, as their protocols often address the impact of varying silica precursor and solvent concentrations. Journals like "Microporous and Mesoporous Materials" or "Journal of the American Chemical Society" frequently publish detailed methodologies that could be directly applicable to your work. Additionally, careful control of synthesis parameters—such as temperature, pH, and aging time—can significantly influence both particle and pore size, so some trial and error in the lab may be necessary.

If you’d like more specific guidance or summaries from particular papers, just let me know! I’m happy to help dig deeper or clarify any protocols. Wishing you the best of luck with your synthesis—please keep me posted on your progress!

Some useful papers to read/cite are:

Chapter Synthesis Of Manganese Oxide Nanoparticles Using Similar Pro...

Article Morphology of single inhalable particle inside public transi...

Article Hierarchical Ni-Mn Double Layered/Graphene Oxide with Excell...

Best regards,

Kaushik

Dendritic mesoporous silica nanoparticles (DMSNs) are a type of porous nanomaterial with a unique branching structure. They have gained attention for biomedical applications due to their large pore size.

The pore size and particle size of MSNs can be controlled by adjusting the synthesis parameters, such as the surfactant chain length and concentration.

Respected, Kaushik Shandilya and Suruthi Periyasamy thankyou for the insightful information. I will consider your recommendations.

It is not exactly what you are asking for, but perhaps it could give you some ideas on how to modify the synthetic path to achieve the desired size and porosity.

Regards

To synthesize mesoporous silica nanoparticles (500–1000 nm) with pore sizes above 10 nm, adjust surfactant types, concentrations, and use swelling agents like TMB in methods for dendritic MSNs, MCM-41, or SBA-15. Control reaction conditions such as pH, temperature, and aging time to tune particle and pore sizes effectively.