I think you can try the standard two sample t-test (unpaired). But I also suggest you try to do a SCI analysis along with the analysis of sample signal energy (SSE). SCI stands for signal content index. Both SCI and SSE are new statistics discussed in "Signal content index (SCI): a measure of the effectiveness of measurements and an alternative to p-value for comparing two means" https://iopscience.iop.org/article/10.1088/1361-6501/ab46fd/pdf