Wefak Jbori Albazi Yes, there is evidence that high cholesterol levels can negatively impact learning and memory.

Here are some paper links that can help you in this regards

Article Alterations in cholesterol metabolism as a risk factor for d...

Article Myelin lipid metabolism and its role in myelination and myel...

Hi Wefak Jbori Albazi

Yes, here's what we know according to literature review:

• Research: Several studies have found an association between high cholesterol and poorer memory performance in adults, particularly middle-aged individuals.
• Possible mechanisms: High cholesterol might affect memory through various mechanisms, including damage to blood vessels leading to reduced blood flow to the brain, inflammation, and changes in the production of brain chemicals necessary for learning and memory.
• Alzheimer's disease link: Some studies suggest hypercholesterolemia might be a risk factor for Alzheimer's disease, a neurodegenerative condition characterized by memory loss and dementia.

References:

• Higher incidence of mild cognitive impairment in familial hypercholesterolemia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844655/
• Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338939/
• Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977849/
• Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients with Alzheimer's Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634658/

Studies indicating a less conclusive link:

• Effects of statins and cholesterol on memory functions in mice: https://pubmed.ncbi.nlm.nih.gov/23606075/

Thanks,

hypercholesterolemia negatively affects the vasculature of the hippocampus