BACKGROUND. I am not a molecular biology expert. I am a retired rheumatologist who dealt with autoantibodies and autoimmune diseases. Rheumatology has been caught up in COVID-19 business via often misguided appropriation of its treatments (hydroxychloroquine, corticosteroids, biologics and colchicine), via patients being sometimes deprived of those treatments because back ordered (rheumatoid arthritis, systemic lupus erythematosus) and via COVID-19 syndromes mimicking rheumatic diseases (Kawasaki in children, anti-phospholipid/lupus/vasculitis and other autoimmune syndromes in adults)
RATIONALE. Currently there are two types of anti-COVID vaccines: the novel, viral-mRNA-driven approach and the classical, viral-protein-driven approach. In the mRNA scheme, delivery of functional mRNA to macrophages, its use to make viral spike protein and its rapid degradation are all within current theory. A marvellous technological achievemen!
QUESTIONS.. What is known about the intracellular processing and migration towards the cell surface of the auto-produced spike protein, about its membrane incorporation and about its presentation as an antigen? Is there any self-membrane moiety wether lipid or protein linked to the spike protein polypeptide? Is there any spike protein shedding and then, does it behave as a regular protein vaccine? While on the cell surface or while shedded, are there neoantigens created which would be part auto, part exo-antigen?
IN SHORT, is there any possibility or evidence of inducing downstream, weeks or months post mRNA vaccine, new auto-immun phenomena or diseases? Currently, there is little or no data to support my worries and, as far as I know, there are no plans to collect any long term follow-up data,. Should there be some? Replacing the COVID-19 pandemic by a man made autoimmune disaster would be the ultimate victory of this most devious virus.
I welcome reassuring thoughts, scientific data, clinical observations or comments?
Covid_19mRNA vaccine is novel one,so great care should be cosidered with autoimmune phenomena because vaccine may trigger the disease
Very interesting point of view and argumentation. For me, your thoughts make sense (but I am not a rheumatologist, neither an auto-immunity specialist). You could even consider developing and documenting it a bit more and publish a letter to editor or a comment with it.
There is a number of speculations how the anti-Corona virus vaccines (already many of them) would and could interfere with certain pathological problems, including auto-immunologic ones. Some colleagues are keen of proposing vaccination within the current auto-immunologic process, which does not correspond to any of the known immunization calendars. I wonder if it would work, or could create additional problems. One other question is also the idea of some teams to introduce vaccination to people who had already gone through the Corona infection and had created certain and good level of immune response. This is, according to my knowledge, a serious mistake and I would be happy to hear other opinions. There are so many still unclear sides of the virus, especially with its new genetic mutations, which could lead to insufficient or even none effect of the present vaccines? What is the issue?
To my observation all heavy diseases following the infection are autoimmunreactions. All patients I have treated during the last 20 years have no B-cells left which can make antibodies against own proteins. Therefore none of my patients will deveopp a heavy disease.
Since 10 years I treat virusinfections intatantly by energetic procedure developped by an Austrian Vetrinarian. This worked also with Ebola, HIV, HPV, Herpes and Varicella Viruses practicall all I found.The treatment is finished within 2 minutes and no parmaceutis are needed, only energetical informed water in teh form of infusion bottels. But nobody is interesterd in my treatment.
https://rheum.ca/wp-content/uploads/2021/02/CRA-Recommendation-on-Covid-19-Vaccination-FINAL.pdf
Research Gate site seems to have problems with transmission
This is a “living” doc. based on published peer reviewd materials. May change as more data becomes available.
Covid_19mRNA vaccine is novel one,so great care should be cosidered with autoimmune phenomena because vaccine may trigger the disease
Corona mRNA vaccine trigger immune reaction, dysregulated , hyperimmune reaction trigger the activation of NF-KB a key transcription factor express immunemediators such as cytokines involved in autoimmune diseases..
Dear Prof Henri A Ménard , severe cases of COVID-19 are already autoimmune disorder featured by cytokine storm, not simple viral infections:
Article COVID-19: Infection or Autoimmunity
Article SARS-CoV-2, the autoimmune virus
As pointed out by Dr Hans H. Gschwender , infection and autoimmune disorder have very high correlations. Escalated diseases after infections are most likely autoimmune diseases.
Dear Dr Yu,
Strictly speaking, the cytokine storm of severe COVID-19 is of the autoinflammatory type and not of the autoimmune type. Have there been reports of bona fide, post-Covid systemic autoimmune rheumatic diseases?
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