I am doing some researches about the 3D structure and binding site of DHFR, I wanted to have any 3D model for BH2 binding with DHFR. I could just find some models for TH2, but not for BH2.
Could some one provide me any model, or paper where I can find such modeling? it is not bad if there were any clear modeling for TH2 as well.
Thanks in advance!
Ramesh K Jha
PDB codes 1DR1, 1DR3, 1DR4, 1DR6 in th eprotein data bank (rcsb.org) is what you are looking for. Relevant publication is:
Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
McTigue, M.A., Davies 2nd., J.F., Kaufman, B.T., Kraut, J.
(1992) Biochemistry 31: 7264-7273
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