Most of the previous studies indicate the importance of the D2 receptor in the regulation of food reward. The papers I have reviewed just indicate that the D2 receptors are effective in food rewarding. However, there is no description for the cellular signaling of these receptors, and it has only been mentioned that binding of dopamine to these receptors inhibit intracellular cAMP levels. Could anyone help me to understand the cellular signaling of food reward?
Richard Premont
Dear Richard Premont
Many thanks for your response. I read the paper you suggested. What I realized was that D2 receptors involve in rewards signaling and various mechanisms which you also mentioned had been identified. D1 and D2 receptors act appose each other. For example, D1 receptors stimulate cAMP-dependent kinase, whereas D2 receptors inhibit it. The question is that which one is responsible for reward?
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