I have been working with nanoparticles with different functional groups. Usually its well known protocol for conjugating cRGD or RGD with COOH functional group but I have a few particles which are amine functionalized, I found 2 articles but I am not yet convinced by different procedures they have used, can someone guide me with the process, if possible with experience and references.
Omar Gonzalez-Ortega
You can change the amino groups to carboxylic groups.
You can use glutaraldehyde to react amino groups using reductive amination.
Both protocols are widely spread in the literature. Hermanson's book has many details.
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Omar Gonzalez-Ortega
Use glutaraldehyde or any other dialdehyde then. Do not forget the reduction step.
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