Colorectal Cancer, Inflammation, and Preoperative Interleukin-6

Sarah Fischbuch @Sarah-Fischbuch-2

01 January 1970 2 6K Report

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Article Interleukin-6 and chronic inflammation

"In chronic inflammation, IL-6 has a detrimental role that favours mononuclear cell accumulation at the site of injury, through continuous MCP-1 secretion, angioproliferation and anti-apoptotic functions on T cells [30]. This may increase serum levels of IL-6 and provide the basis for the amplification step of chronic inflammatory proliferation."

Interleukin-6 is released by monocytes and macrophages in response to other inflammatory cytokines which include interleukin-11, and tumor necrosis factor (TNF)-beta.

Chapter Chronic Inflammation

"Chronic inflammation can result from the following:

Failure of eliminating the agent causing an acute inflammation such as infectious organisms including Mycobacterium tuberculosis, protozoa, fungi, and other parasites that can resist host defenses and remain in the tissue for an extended period.

Exposure to a low level of a particular irritant or foreign materials that cannot be eliminated by enzymatic breakdown or phagocytosis in the body including substances or industrial chemical that can be inhaled over a long period, for example, silica dust.

An autoimmune disorder in which the immune system is sensitized to the normal component of the body and attacks healthy tissue giving rise to diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE).

Recurrent episodes of acute inflammation. However, in some cases, chronic inflammation is an independent response and not a sequel to acute inflammation for example diseases such as tuberculosis and rheumatoid arthritis.

Inflammatory and biochemical inducers are causing oxidative stress and mitochondrial dysfunction such as increased production of free radical molecules, advanced glycation end products (AGEs), uric acid (urate) crystals, oxidized lipoproteins, homocysteine, and others."

Cytokine Panel (ARUP):

Interleukin 2 Receptor (CD25) Soluble

Interleukin 12

Interferon gamma

Interleukin 4

Interleukin 5

Interleukin 10

Interleukin 13

Interleukin 1 beta

Interleukin 6

Interleukin 8

Tumor Necrosis Factor - alpha

Interleukin 2

Interleukin 17

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