Clozapine n-oxide dihydrochloride vs clozapine n-oxide?

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Anyone have experience with the "RABv/RphiGT" mouse (JAX 024708) mouse?

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Has anyone experienced a problem using staining with Neurotrace where it appears as if mainly the nucleoli are stained & somal staining is weak?

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06 July 2018 7,496 0 View

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01 February 2018 4,362 2 View

How can I measure MMP-1 protein activity or protein level from liver tissue?

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IHC on mouse liver hepatocytes?

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Interested to stain mice tissue with WGA 488 conjugate, anybody has a protocol to recommend?

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Why do my MCFs not form monolayer?

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What are the pros and cons for mice versus rats?

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Is it harmful to breed for Cre Homozygosity initially?

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How to empty large intestine in mice ?

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Jeremy C. Borniger

it should work just as well. We are moving towards using the new ultrapotent ligand "J60 - hydrochloride" which does not need to be metabolized into clozapine to work.

https://www.hellobio.com/jhu37160-dihydrochloride.html

Samantha Roome

We don't anticipate any differences in pharmacological activity between the freebase and dihydrochloride salt of CNO, but they do differ a little in stability and handling - you can see some the detailed info here:

https://www.hellobio.com/stability-of-water-soluble-dreadd-ligands-in-solution-a-technical-review/

Hope this helps!

Sam