How hydrophobic polymers as cellulose and lignin can be used as efficient nanoparticles for poorly water-soluble agent delivery in aqueous environment (blood, extracellular fluid, in vitro culture media) ??
Generally, the nano carriers can be in two categories of hollow particles where the substance is encapsulated; or solid and porous particles infused with the carried substance. In the first approach, the hydrophobic drug can for example incorporated in the oil particle core by dissolving it in the oil phase. In the second approach, the drug can be mixed with the solvent and incorporated in to lignin nanoparticles during the precipitation process.
Using appropriate surfactants in biological environments that can accommodate the desired nanoparticles in the environment, otherwise the body's immune system automatically detects and remove the nanoparticles quickly. You really need to increase the biocompatibility of the hydrophobic nanocarreirs with use of substances mentioned above.
@Mohammad Issawi These articles could help:
https://www.researchgate.net/publication/334761263_Chemo-enzymatically_prepared_lignin_nanoparticles_for_value-added_applications
https://www.researchgate.net/publication/333067906_Lignin_for_Nano-_and_Microscaled_Carrier_Systems_Applications_Trends_and_Challenges
The second one is precisely about lignin as nanocarriers. The answer is a bit late, but if you are still interested I think it could help you.
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