I am working on a protein that is approximately 300-600 amino acids in length. To design my in vivo study protocol, I need to predict the potential pharmacokinetics (PK) of this protein. However, using the ProtParam tool from ExPASy does not provide reliable results for predicting the ADME (absorption, distribution, metabolism, excretion) properties that would inform PK.

Can anyone suggest any authentic computational tools or methods that could help predict the ADME and PK profile of my protein drug candidate based on its amino acid sequence and other available data? I am looking for in silico approaches that can provide reasonably accurate PK predictions to guide my in vivo study design.

Any suggestions or insights into computational tools and best practices for predicting protein drug PK would be greatly appreciated.