Hello every bio-field expert, professor, researcher:
Our experiment design aims to induce the immune system, to affect the tumor cell progress. In the previous study, we found a connection between programmed death proteins and the immune system, our final goal was to combine them with monoclonal antibodies or adoptive T-cell therapy.
This time, we're planning to knock out a "key gene" to do the experiment, if this cell is not that sensitive to induce Immunogenic, our effectiveness would be lower than expected.
Hopefully, can get your help, thanks for your reading.
Dear Ya Hui Zhang You can try microglia cells. Because microglia cells are the main cells of the immune response in the brain.
Best Regard
Hi Ya Hui Zhang
I agree with Eda. You can use microglial cells and astrocytes. Microglia would be more appropriate as it is readily activated in presence of toxins and induces phagocytic properties by releasing inflammatory cytokines.
Thanks,
Samir