Can you compare AMPA/NMDA ratio between mouse strains?

16 April 2018 1 4K Report

I've read that you can only compare AMPA/NMDA ratio before and after drug treatment as the value itself doesn't mean anything. Is this true? Can you compare AMPA/NMDA ratio between mouse strains without drug treatment, e.g. WT and a genetic KO? The purpose is to look at the underlying molecular mechanisms for the behavioural/cognitive differences observed in different mouse strains.

Thanks!

Abdallah Hussien Fathy

The following links will solve the problem

https://www.nature.com/articles/s41598-017-12368-6

Article Enhancement of contextual fear-conditioning by putative (+/-...

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