Wildtype zebrafish, despite lacking classical mast cells, possess mast cell-like cells that release histamine, offering a simplified model for studying allergic responses. Their genetic accessibility and transparency enable efficient investigation of mast cell degranulation mechanisms. Leveraging these advantages, zebrafish provide a cost-effective and ethically sound platform for understanding allergic pathophysiology and developing potential therapies. What are experts' thoughts on the utility and limitations of using zebrafish in allergic response research, and how can these insights guide future investigations?
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