The Golden Ratio is generally used in mathematics and arts science based on Fibonacci number. Definitely we have used this technique after the great mathematician, i.e. nature. You can see that nature has used this everywhere like in sunflower, stem and branch arrangement in plant, petals and most importantly the DNA. DNA molecule 21 A width and 34 A length are two Fibonacci number obeying this rule. Also the minor and major groove of the DNA shows similar results.Taking account of DNA chromosomal arrangement there should be a mathematical view of genome function, i.e. DNA replication and repair to gene expression and mutation, breaking, joining of DNA double strand or single strand,,RNA and proteins structure, etc.