Though I haven't directly worked with this compound, my lab has previously administered antalarmin ICV using carboxymethylcellulose (0.5%) and DMSO. According to our records, for IP injections in mice, we made a suspension in deionized water with 0.5% carboxymethylcellulose (using a stir plate for up to 15 min). However, I don't think we used doses as high as 10 mg/kg. Feel free to email me if you have other questions!
Also see this link for an alternative (Funk et al., 2014).
Ey Rachel! Thank you so much for the tip! I think centrally it can be administered more easily, even mixed with plain saline. IP seems to be more difficult, thanks a lot!
We have used DMSO to administer steroids via subcutaneous injections. It does cause acute pain at the injection site but we have seen no other adverse effects.
For humans I would suggest only using DMSO as the vehicle if you are administering the drug via transdermal absorption with a patch rather than via injection.
We have tried using topical lidocaine to reduce pain at the injection site in rats but the effectiveness is limited.
If you do not mind my asking why do want to inject DMSO into humans?