No.. Lyophiliser is better to us then desiccator. Please refer some useful research article showing benefits of lyophiliser over other methods.

no we cannot use desiccators for drying of SLN,hence this is the reason

During this storage period, the particle size, shape and drug entrapment should be maintained in order to retain functional activity. But due to their rapid deterioration by aggregation, aqueous formulations cannot be stored for long periods of time, either at room temperature or at 4°C. This limits their utility as a viable option for therapeutic application on a long-term basis. Moreover, preparation of fresh formulations at the patient’s bedside requires proper training of the health care providers, which is often difficult to fulfill (Caplen et al., 1995). In this context, lyophilization appears to be a feasible approach to solve this problem. Lyophilized powders can be stored at 4° C or even at room temperature for extended time periods and can be reconstituted in a reproducible manner immediately prior to use (Reinisalo et al., 2006).

There is a problem with using dessicators as these need some dessicating agents like sulfuric acid or activated silica. These may also impact the structure of the nano sized drug carriers. Also this method is not a good assurance that formulation has lost complete moisture. 

Dear All expert,

I have a problem, actually I made solid lipid nanoparticle, but frezee-dry in our lab still in trouble so it is imposible to use right now. The posible choices is only send my samlple to other lab. Unfotunately, it will spend about 15 to 20 of days. Any suggestion for storage during shipping? Or It is posible to make freeze dry by ourselves?

Thanks