the the levofloxacin disintegrates in stomach.. Can we make it colon specific by using enteric coating so that it absorption take place in colon??
No...Only by giving enteric coating, It will not possible to target colon region. For making colon targeted dosage forms, you require few more polymers that even protect drug and dosage form in small intestine region.
Levofloxacin is a weakly acidic drug with carboxylic acid moiety. pKa value = 6.24 and as per handerson hasselbalch equation drug will not shows ionization in any pH below 6.24 thus drug will be completely insoluble in gastric fluid (stomach). Drug will be soluble only if the pH of the medium increases above 6.24. So, ideal for colon delivery.
But for this drug matrix formulation will also be much better as compared to enteric coating since drug is itself not soluble in acidic pH and as coating increase cost of formulation then you should go for matrix of levofloxacin using Eudragit as retarding polymer which do not shows any disintegration in stomach. One more important is permeability of drug which is very less and for this addition of some lipid particles is necessary.
Thanks alot sir @Rahul Gupta for this useful information can you send me the link to literature you are refering i.e about its pka value !
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