I am currently doing CT imaging research on mouse brain tumors. The CT images produced by the laboratory before were difficult to observe the tumor boundary and growth status. If anyone has used this contrast agent to do similar brain tumor imaging, or has read related research, could you please share your experience? For example, details such as injection dose and imaging time. Thanks in advance!
Yes, Ioversol (MP-328) (HY-B1410, MCE) can be used for CT contrast enhancement. Ioversol is a non-ionic, low-osmolar iodinated contrast agent that enhances the X-ray attenuation of tissues, thereby increasing the contrast between specific tissues (such as articular cartilage or tumors) and surrounding structures in CT images, allowing for clearer visualization of their morphology and boundaries.
Practical applications reported in the literature include:
(1) In articular cartilage imaging, a 30% concentration of Ioversol can significantly differentiate the CT attenuation values of cartilage from those of bone and background, achieving effective enhancement (PMID: 32683740). The signal reaches equilibrium within 5 minutes and remains stable for up to 60 minutes.
(2) In tumor models, intravenous injection results in an iodine concentration in the tumor region of approximately 2 mg I/mL, significantly increasing the CT signal, with the enhanced area mainly distributed at the tumor margins. Within 30 minutes post-injection, the iodine concentration in the tumor region remains stable (fluctuates within 20% of the mean) (PMID: 26460826).
Detailed protocols for in vitro and in vivo imaging using Ioversol can be found in PMID: 32683740 and PMID: 26460826, respectively.
The answer to this question comes from MedChemExpress (MCE) Technical Support.
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