Hi !

Your question is too broad ...if you can say in which domain and with what resources you are moving. May be one can project precise suggestion. Still, i would like to enlist few topics....just go through them and see if you can align yourself and your university desk accordingly:

• Development of 3D Printed Personalized Tablets – For individualized dosing and controlled drug release in chronic diseases.
• PLGA-Based Nanoparticles for Nose-to-Brain Drug Delivery – Targeting Alzheimer’s, epilepsy, or depression through intranasal delivery.
• Smart pH-Responsive Hydrogels for Colon-Specific Drug Delivery – Triggered release for IBD, Crohn’s disease, and colorectal cancer.
• Formulation of Transferosomal Gel for Transdermal Delivery – Non-invasive delivery for pain management or hormone therapy.
• Mucoadhesive Buccal Films of Herbal Extracts – Local therapy for oral ulcers using turmeric, licorice, or neem.
• Self-Nanoemulsifying Drug Delivery System (SNEDDS) – Enhancing oral bioavailability of BCS Class II drugs like itraconazole.
• Nanocrystals for Solubility Enhancement – Improving dissolution of poorly soluble drugs using antisolvent method.
• Thermosensitive In-Situ Gel for Ophthalmic Drug Delivery – Long-acting eye drops for glaucoma or conjunctivitis.
• Microneedle Patch for Transdermal Vaccine Delivery – Painless, self-administered vaccine technology for future pandemics.
• Lipid-Based Nanocarriers for Targeted Chemotherapy – Safer IV formulation of hydrophobic anticancer drugs like paclitaxel.

Pls feel free to discuss further.

Development of Dissolvable Microneedle Patch for Transdermal Delivery of Insulin Need it solves: Non-invasive delivery of large molecules like peptides. Scope: Can extend to vaccines, hormones,…

For an M.Pharm thesis in Pharmaceutics, numerous innovative research directions are available focusing on current industry needs and scientific advancements. Nanotechnology-based drug delivery systems offer promising options such as developing solid lipid nanoparticles to enhance oral bioavailability of poorly soluble BCS Class II drugs like curcumin or ritonavir. Targeted cancer therapy could explore ligand-conjugated polymeric micelles for tumor-specific delivery of paclitaxel using folate or transferrin targeting. Emerging 3D printing technology presents opportunities for developing fused deposition modeling (FDM) printed sustained-release metformin tablets using optimized HPMC/PVA blends. Natural polymer research could focus on chitosan-alginate nanoparticles for improved ocular delivery of moxifloxacin with enhanced corneal retention. Transdermal delivery systems might investigate iontophoretic delivery of donepezil hydrochloride for Alzheimer's treatment using terpene permeation enhancers. Biopharmaceutics projects could employ PBPK modeling with GastroPlus™ to predict food effects on posaconazole absorption. Pediatric formulations need innovation in taste-masked orodispersible films of azithromycin using ion-exchange resins. Green pharmacy approaches could explore solvent-free microwave synthesis of ibuprofen cocrystals with succinic acid. Inhalation therapy research might optimize levofloxacin dry powder inhalers using lactose carriers for tuberculosis treatment. Artificial intelligence applications could include machine learning optimization of nanoemulsion formulations for dermal delivery. Vaccine delivery systems could investigate lyophilized PLGA microparticles for oral HPV vaccines. Herbal nanomedicine might explore niosomal berberine for enhanced antidiabetic effects. Personalized medicine could develop 3D printed patient-specific chewable sildenafil tablets for pediatric pulmonary hypertension. Quality-focused research might apply QbD principles to generic extended-release venlafaxine development. Smart drug delivery systems could design pH-responsive Eudragit® S100 hydrogels for colon-specific mesalamine delivery in ulcerative colitis. Selection should consider laboratory capabilities, novelty potential, and alignment with current pharmaceutical industry priorities and regulatory trends. The chosen topic should balance innovation with practical feasibility within available resources and time constraints.

e.g. "A design of a suppository to be of a local and general phatmacological activvity in the colon".

Here are three new, interesting, and genuinely useful pharmaceutics research topics that are fresh enough for M.Pharm and have strong practical value:

1. AI-Guided Personalized 3D-Printed Tablets

Idea:

Develop a 3D-printed oral dosage form where drug dose and release profile are personalized based on patient parameters (weight, metabolism, disease severity). AI software predicts the optimal tablet design, which is then printed on demand.

Why it’s new & useful:

Bridges pharmaceutics with AI & 3D printing.

High clinical relevance in elderly, pediatric, and multi-drug patients.

Publication potential in top pharmaceutics journals.

2. Smart pH-Responsive Nanocarriers for Targeted Antibiotic Delivery

Idea:

Formulate polymer-coated nanoparticles that release antibiotics only in infection sites where local pH is acidic (due to bacterial metabolism).

Why it’s new & useful:

Minimizes systemic side effects and antibiotic resistance.

Highly relevant in the fight against multi-drug resistant bacteria.

Can be tested using bacterial culture models in your lab.

3. Self-Healing Hydrogel Wound Dressings with Built-in Drug Delivery

Idea:

Create a biopolymer hydrogel that can self-repair if damaged and continuously release antimicrobial and healing agents to chronic wounds (like diabetic ulcers).

Why it’s new & useful:

Addresses real clinical need in diabetic and elderly populations.

Combines material science with pharmaceutics.

High chance of patentability and collaboration with medical device companies.

If you want, I can pick one of these topics and prepare:

A full M.Pharm research proposal (introduction, objectives, methodology, expected results, references).

Ensure it’s doable in a standard Indian pharmacy college lab and still novel enough to impress examiners and journals.

I think the pH-responsive antibiotic nanocarrier is especially relevant and doable with your nanocarbon experience.