under biopharmaceutics classification system class 2 and 4 drugs have poor water solubility. by making them as solid dispersions their solubility can be increased. is there a specific method to measure whether the solubility has been increased in-vitro?
Dissolution test can be one of the methods used to examine the solubility and the bioavailability of drugs in vitro
Sisara Vithana
Micronization
Sonocrystalisation
Nanosuspension
Supercritical fluid process
Solubilizing agents
Selective adsorption on insoluble carrier
Solvent deposition
Using soluble prodrug
Functional polymer technology
Precipitation Porous
microparticle technology
Nanotechnology approaches
Using Complex with Cyclodextrin, Fusion method, pH change method, Lyophilization , using surfactants, micronization of particles enhance surface area and also improve solubility and dissolution
Specifically intrepreated by using UV spectrscopic method for finding for solubility with different temperatures and processing conditions
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- Clinical Pharmacology
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