I am working on the subcutaneous delivery of hydrophobic drugs. For characterization of my prototype formulations , I need an in vitro model mimicking the subcutaneous site. Simple dialysis method may not work for me. Any suggestions please???
(i) Skin models for the testing of transdermal drugs. Eman Abd, Shereen A Yousef, Michael N Pastore, Krishna Telaprolu, Yousuf H Mohammed, Sarika Namjoshi, Jeffrey E Grice, and Michael S Roberts. Clin Pharmacol. 2016; 8: 163–176.
(ii) Use of in vitro release models in the design of sustained and localized drug delivery systems for subcutaneous and intra-articular administration. S. W. Larsen, J. Østergaard, A. Yaghmur, H. Jensen, C. Larsen. Journal of Drug Delivery Science and Technology, 2013, 23 (4), 315-324.
(iii) https://www.genoskin.com/en/tissue-samples/skin-model-subcutaneous-injections/
Disclaimer: I have no affiliation with any person or company listed above in my answer.
@ Rohit singh..Thank you Rohit sir for your input. Genoskin technology looks very interesting and may suit for us.
You may also check the following:
https://www.straticell.com/en/In-Vitro-Skin-Models
Thank u Gitu Pandey Mam...Straticell provide in vitro skin testing of cosmetic products. We are specifically interested in subcutaneous absorption or release models after sc administration.
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