Hi,
I need to get my hands on a smaller amount of HB-19 peptide and wonder if someone has previously ordered it from a commercial source. I am not a chemist and I don't know how hard it is to make, and unfortunately I don't have any contacts myself for making it. Would appreciate your help.
Best,
David
David: Get the sequence of HB-19, send it to a biotech company to synthesize for ~$200 for 1-4 mg with 95% purity. We used a company called LifeTein in NJ, USA, and can give you the contact info if you are interested.
@David
According to this J. Biol. Chem. research article, the authors purchased HB-19 from Polypeptide Laboratories in Strasbourg, France:
http://www.jbc.org/content/early/2012/11/16/jbc.M112.387076.full.pdf
Here is the website for the Polypeptide Group; they apparently have direct sales operations in Limhamn, Sweden. Presumably, they can remake the peptide to the same (if not better) specifications as before by comparisons with the Quality Control data for the original batch:
http://www.polypeptide.com/polypeptide-contact-us/p39.html
NOTE: The structure of HB-19 is more complicated than a typical peptide. It contains several unnatural amino acids. Contract manufacturers may charge extra money for unnatural amino acids or difficult purification processes. Here are other established contract manufacturers of research peptides with European operations:
• Cambridge Research Biochemicals (UK)
http://www.crbdiscovery.com/services/peptide-synthesis/
• BA-CHEM (Switzerland)
https://www.bachem.com/contact/
• Innovagen (Sweden)
http://www.innovagen.com/custom-peptide-synthesis-service
If your budget is limited, you may consider contacting Professor Ara G. Hovanessian at the CNRS UFR Biomedicale-Université René Descartes in Paris, France. He has published extensively with HB-19 (examples below, see contact information). He also has a ResearchGate profile and may have a reliable supply of HB-19 (see below).
http://www.nature.com/cr/journal/v16/n2/full/7310024a.html
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424174/
http://www.jbc.org/content/274/39/27875.full.pdf
http://www.researchgate.net/profile/Ara_Hovanessian2
Alternatively, you may consider asking your local Chemistry Department if it offers peptide synthesis services. Hope this information helps.
http://www.chemistry.umu.se/kontakta-oss/?languageId=3
Thanks for all your help I will look into the best option for me. I have already emailed Prof. Ara G. Hoveanessian but have not received a reply. I am also talking to my local chemists but but not sure they can make it as fast as I need it and to the quantities I need. Still working on that.
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