There are case reports of Rifampicin being used in Primary Biliary Cirrhosis and for treatment of pruritus in Cholestatic hepatitis. But can it cause cholestatic hepatitis itself?
Rifampin is also associated with rare instances of clinically apparent liver injury accompanied by symptoms and jaundice, which can be severe and even fatal
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773428/&ved=2ahUKEwjq4ZezuePzAhX3g_0HHfmODdQQFnoECDQQAQ&usg=AOvVaw0mpnUHm5y9CR2ta5oXM39V
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.hindawi.com/journals/crihep/2020/8872804/&ved=2ahUKEwjq4ZezuePzAhX3g_0HHfmODdQQFnoECBUQAQ&usg=AOvVaw1JxNUn2woqEXp8z9AuYWq6
https://www.google.com/url?sa=t&source=web&rct=j&url=https://adc.bmj.com/content/archdischild/69/1/141.full.pdf&ved=2ahUKEwjq4ZezuePzAhX3g_0HHfmODdQQFnoECEcQAQ&usg=AOvVaw0lbbSQvFgu8K8CIz2kbNol
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.atsjournals.org/doi/10.1164/rccm.200510-1666ST&ved=2ahUKEwjq4ZezuePzAhX3g_0HHfmODdQQFnoECBMQAQ&usg=AOvVaw3-ySCie7kpi4wRnwnQjrYY
https://www.google.com/url?sa=t&source=web&rct=j&url=https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-14-S7-P48&ved=2ahUKEwjq4ZezuePzAhX3g_0HHfmODdQQFnoECDoQAQ&usg=AOvVaw2er88Q7ojg5a9jBhiObtIY
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.gastrojournal.org/article/0016-5085(90)90027-X/pdf&ved=2ahUKEwjk4e3kuePzAhUpRPEDHapnCGY4ChAWegQIARAB&usg=AOvVaw3BZdpdff4j29tPEnc-nvgP
Thank you Dr Faris,
The case report in BMC infectious disease is very interesting__though it does not shed much light. But Nonhepatitis jaundice is a new concept.
Rifampicin induced Jaundice may be [1] just an increase in bilirubin level with normal enzymes -- [a] indirect due to impaired uptake at sinusoidal level, [b] direct due to impaired excretion by blocking the BSEP [cholestatic "jaundice" or [2] drug induced hepatitis mostly idiosyncratic due to allergic reaction [flu like syndrome] but sometimes dose related. Isolated cholestatic "hepatitis" is rare but can occur insidiously. Polypharmacy or presence of other disease may influence it.
Of course, it is. You must know this and treat only patients without liver disease and with strict follow-uop of every case
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