I planned to develop Proliposomes and provide via oral route to improve the bio-availability of the drug which is extensively metabolized in the liver. I found certain literature stating it can avoid first pass metabolism. If anyone is aware about this can share their views.
Thanks in advance.
Thanks for the share.
It will be great if you could share how proliposomes are prepared? I tried to find but unable to find that.
Hello!
As per the established scientific literature proliposomes were one of those delivery systems which has proven to over come pre-systemic or first pass metabolism by enhancing lymphatic transport. However, practical evidence has to furnished for better understanding of this concept. Proliposomes offer good potentiality for those drugs with low solubility and/or permeability limitations.
for your reference and proceeding further, here i attach my work (published)
Article Bioavailability enhancement of zaleplon via proliposomes: Ro...
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